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导师介绍
董惠钧
作者: 发布日期:2022-03-20



硕士生导师简历

  1. 基本信息                                      

姓名:董惠钧

职称:教授

学历:博士

电话:18769565975

电子信箱:donghuijun_747@163.com

出生年月:1977.04

研究方向:(1)糖肽类抗生素生物合成和改造(2)药食两用真菌和药食同源中药相关健康产品的开发和应用研究(3)双抗DNA药物的研究。

毕业学校:浙江大学

务:

  1. 研究工作简介

(1)       糖肽类抗生素生物合成和改造:建立和优化适用于稀有放线菌的基因编辑和关键酶定向进化策略通过糖肽类抗生素生物合成途径和调控网络编辑和改造,消除同系物杂质和色素的产生,建立高效的糖肽类抗生素生物合成体系。

(2)       药食两用真菌和药食同源中药相关健康产品理论和应用研究:以珍稀药用真菌和药食同源中药为研究对象,围绕慢性疾病调理和亚健康身体机能失调,研究和开发健康食品和功效评价。

(3)       双抗DNA药物的研究:以大肠杆菌和毕赤酵母为底盘细胞,借助in silico方法,开展双抗DNA药物设计、表达纯化、递送系统和应用评价灯研究

  1. 近三年发表论文

[1] Bingyu Yan, Wen Gao, Li Tian, Shuai Wang, Huijun Dong. Production enhancement of the glycopeptide antibiotic A40926 by an engineered Nonomuraea gerenzanensis strain. Biotechnology Letters (2021). https://doi.org/10.1007/s10529-021-03210-1

[2] Wen Gao, Li Jin, Chunhong Liu, Ning Zhang, Ruiyan Zhang, Zuzana Bednarikova, Zuzana Gazova, Anirban Bhunia, Hans-Christian Siebert, Huijun Dong*. Inhibition behavior of Sennoside A and Sennoside C on amyloid fibrillation of human lysozyme and its possible mechanism. International Journal of Biological Macromolecules, 2021,178:424-433.

[3] Ning Zhang, Li Jin, Chunhong Liu, Ruiyan Zhang, Hans-Christian Siebert, Yanhui Li, Gabriele Loers, Athanasios K. Petridis, Zhangyong Xia, Huijun Dong, Xuexing Zheng. An antarctic krill oil-based diet elicits neuroprotective effects by inhibiting oxidative stress and rebalancing the M1/M2 microglia phenotype in a cuprizone model for demyelination. Journal of Functional Foods, 2021, 76:104309-104323.

[4] Huijun Dong, XueYue, BingyuYan, WenGao, ShuaiWang, Yongquan Li. Improved A40926 production from Nonomuraea gerenzanensis using the promoter engineering and the co-expression of crucial genes. Journal of Biotechnology, 2020, 324:28-33.

[5] Li Jin, Wen Gao, Chunhong Liu, Ning Zhang, Shruti Mukherjee, Ruiyan Zhang, Huijun Dong, Anirban Bhunia, Zuzana Bednarikova, Zuzana Gazova, Min Liu, Jun Han, Hans-Christian Siebert. Investigating the inhibitory effects of entacapone on amyloid fibril formation of human lysozyme[J]. International Journal of Biological Macromolecules, 2020, 161:1393-1404.

[6] Xue Yue, Tianyu Xia, Shuai Wang, Huijun Dong, Yongquan Li. Highly efficient genomic editing in N. gerenzanensis using an inducible CRISPR/Cas9/RecA system[J]. Biotechnology Letters, 2020, 42:1699-1706.

[7] Xue Yue, Bingyu Yan, Shuai Wang, Wen Gao, Ruiyan Zhang, Huijun Dong. Preparation of pH-responsive alginate–chitosan microspheres for L-Valine loading and their effects on the A40926 production[J]. Current Microbiology, 2020, 77: 1016-1023.

[8] 孙苗苗, 李向阳, 李华利, 刘红粉, 王帅, 张瑞岩, 董惠钧. 鲜鸡肠与鸭肠、鹅肠中金属元素含量对比研究[J]. 食品安全质量检测学报, 2020, 11(6):1992-1996.

[9] 岳雪, 王帅, 李大成, 王勇健, 董惠钧. 野野村放线菌ATCC 39727的双组份信号转导系统的生物信息学分析[J]. 中国抗生素杂志, 2019, 4:413-421.